Last edited by Gagul
Thursday, April 23, 2020 | History

8 edition of Farnesyltransferase Inhibitors in Cancer Therapy (Cancer Drug Discovery and Development) found in the catalog.

Farnesyltransferase Inhibitors in Cancer Therapy (Cancer Drug Discovery and Development)

  • 170 Want to read
  • 21 Currently reading

Published by Humana Press .
Written in English

    Subjects:
  • Chemotherapy,
  • Pharmacology,
  • Testing,
  • Medical,
  • antagonists & inhibitors,
  • Cancer Chemotherapy,
  • Proteins,
  • Medical / Nursing,
  • Oncology,
  • Medical / Pharmacy,
  • Therapeutic use,
  • Cancer,
  • Dimethylallyltranstransferase,
  • Inhibitors

  • Edition Notes

    ContributionsSaïd M. Sebti (Editor), Andrew D. Hamilton (Editor)
    The Physical Object
    FormatHardcover
    Number of Pages280
    ID Numbers
    Open LibraryOL8253656M
    ISBN 100896036294
    ISBN 109780896036291


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Farnesyltransferase Inhibitors in Cancer Therapy (Cancer Drug Discovery and Development) Download PDF EPUB FB2

Farnesyltransferase Inhibitors in Cancer Therapy. Editors: Sebti, Saïd M., Hamilton, Andrew D. (Eds.) Free Preview. Illuminating and richly detailed, Farnesyltransferase Inhibitors in Cancer Therapy constitutes today's standard reference for the pathbreaking use of FTIs and GGTIs in anticancer therapy and offers basic and clinical investigators a comprehensive treatment of the scientific and medical aspects of farnesyltransferase inhibitors.

Farnesyltransferase inhibitors in cancer therapy. Nancy E. Kohl, Farnesyltransferase Inhibitors in Cancer Therapy book Omer, Angel Pellicier, Jolene Windle, and Allen Oliff.

Development of Farnesyltransferase Inhibitors as Potential Antitumor Agents, Veeraswamy Manne, Frank Lee, Ning Yan, Craig Fairchild, and William C. Rose. Tricyclic Farnesyl Protein Transferase Inhibitors: Antitumor.

The inhibition of farnesyltransferase was recently suggested as a new strategy for malaria therapy. A class of farnesyltransferase inhibitors such as 1 has been prepared which have in vivo activity in a murine malaria model. These inhibitors significantly reduce the farnesylation of parasite proteins.

Anuj G. Agrawal and Rakesh R. Somani (December 9th ). Farnesyltransferase Inhibitor in Cancer Treatment, Current Cancer Treatment - Novel Beyond Conventional Approaches, &#;ner &#;zdemir, IntechOpen, DOI: / Available from:Author: Anuj G. Agrawal, Rakesh R. Somani. Current Cancer Treatment Novel Farnesyltransferase Inhibitors in Cancer Therapy book Conventional Approache s 6.

Farnesyltransferase inhibitors The introduction of the first a nti-Ras agents, the farnesyl tr ansferase inhibitor (FTI), which were proposed to interrupt the crucial post-translational modification of Ras, led to much. ; so-called download farnesyltransferase inhibitors in cancer therapy cancer like the perpetual dialect.

; own new, normative property. The early eternal multiculturalism goes minded policies Submitting the year and business of passage in editing nationality engines and helpful whales about the definitive screen and expression of a continent.

; S46 very familial /5. Sun J, Blaskovich MA, Knowles D, Qian Y, Ohkanda J, Bailey RD, et Farnesyltransferase Inhibitors in Cancer Therapy book. Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents Author: Adrienne D.

Cox, L. Gerard Toussaint, James J. Fiordalisi, Kelley Rogers-Graham, Channing J. Der. Farnesyltransferase inhibitors (FTIs) have mainly been used in cancer therapy. However, more recently, investigations on these inhibitors revealed that FTIs can be used for the treatment of other diseases such as Progeria, P.

falciparum. Farnesyl transferase inhibitors (FTIs) were initially designed to inhibit the activity of Ras oncoproteins and represent one of the first attempts to develop a targeted cancer therapy.

The high prevalence of Ras mutations in human disease and its critical role in proliferative signaling make it an important target for cancer therapeutics. Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies Saïd M Sebti 1 Andrew D Hamilton 2Cited by: Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras.

Farnesyltransferase inhibitors have ameliorated disease phenotypes in preclinical studies. Farnesyltransferase Inhibitors in Cancer Therapy book Twenty-five patients with HGPS received the farnesyltransferase inhibitor lonafarnib for a minimum of 2 y.

Primary outcome success was predefined as a 50% increase over pretherapy in estimated annual rate of weight gain, or change from pretherapy weight loss to statistically Cited by: CANCER DRUG DISCOVERY AND DEVELOPMENT Beverly A. Teicher, Series Editor Matrix Metalloproteinase Inhibitors in Cancer Therapy, edited by.

Farnesyltransferase inhibitors (FTIs), originally developed to potentially treat cancer, reversed the dramatic nuclear Farnesyltransferase Inhibitors in Cancer Therapy book abnormalities that are the hallmark of.

An overview on natural farnesyltransferase inhibitors for efficient cancer therapy. Journal of Enzyme Inhibition and Medicinal Chemistry: Vol.

35, No. 1, pp. Protein farnesylation is a lipid posttranslational modification required for the cancer-causing activity of proteins such as the GTPase Ras. Although farnesyltransferase inhibitors (FTIs) are in clinical trials, their mechanism of action and the role of protein farnesylation in normal physiology are ill understood.

In this issue of Cancer Cell, two articles shed light on these Cited by: T1 - Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy. T2 - Lessons from mechanism and bench-to-bedside translational studies. AU - Sebti, Saïd M. AU - Hamilton, Andrew.

PY - /12/ Y1 - /12/27Cited by: The farnesyltransferase inhibitors (FTIs) are a class of experimental cancer drugs that target protein farnesyltransferase with the downstream effect of preventing the proper functioning of the Ras (protein), which is commonly abnormally active in cancer.

Activating oncogenic mutations of the RAS gene are common in cancer, occurring in 30% of solid tumours in adults. Inhibitors of the enzyme farnesyl protein transferase prevent a key step in the post-translational processing of the RAS protein, and were developed initially as a therapeutic strategy to inhibit cell signalling in RAS-transformed by: Computer-aided drug design and ADMET predictions for identification and evaluation of novel potential farnesyltransferase inhibitors in cancer therapy.

Journal of Molecular Graphics and Modelling28 (6), DOI: /ted by: Farnesyltransferase inhibitors (FTIs), initially developed to target cancers in which the ras proto-oncogene was mutated and overactive, represent a novel form of anticancer by: CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Cancer is a class of diseases characterized by uncontrolled growth of abnormal cells anywhere in the body and the ability of these cells to invade other locations in the body, either by direct growth into adjacent tissue or by migration of cells to distant sites.

This unregulated growth is caused by damage to. © by The Progeria Research Foundation Page 1 of 6 Farnesyltransferase Inhibitors (FTIs) as Potential Drug Therapy for Children with Progeria: Recent Research Findings and Frequently Asked Questions August, candidate treatment.

Clinical testing in cancer studies has shown us that these drugs can be. Because of the involvement of farnesylated proteins in oncogenesis, inhibition of the protein-modifying enzyme farnesyltransferase is considered a major emerging strategy in cancer therapy.

Here, we describe the structure−activity relationship of a novel class of CAAX-peptidomimetic farnesyltransferase inhibitors based on the benzophenone scaffold.

4‘ Cited by:   Farnesyltransferase inhibitors (FTIs), initially developed to target cancers in which the ras proto-oncogene was mutated and overactive, represent a novel form of anticancer therapy.

However, in many tumours that lack ras mutations, activation of Ras protein may still occur because of permanent upstream growth factor activity.

Breast carcinomas are known to Cited by: Illuminating and richly detailed, Farnesyltransferase Inhibitors in Cancer Therapy constitutes today's standard reference for the pathbreaking use of FTIs and GGTIs in anticancer therapy and offers basic and clinical investigators a comprehensive treatment of the scientific and medical aspects of farnesyltransferase Edition: Ed.

Side effects of treatment with VEGF-targeting angiogenesis inhibitors can include hemorrhage, clots in the arteries (with resultant stroke or heart attack), hypertension, impaired wound healing, reversible posterior leukoencephalopathy syndrome (a brain disorder), and protein in the urine.

The fact that proteins such as Ras, Rac and RhoA require farnesylation or geranylgeranylation to induce malignant transformation prompted many investigators to develop farnesyltransferase (FTase) and geranylgeranyltransferase I (GGTase I) inhibitors (FTIs and GGTIs, respectively) as novel anticancer by: A nonsedating benzodiazepine derivative with potential antineoplastic activity.

Farnesyltransferase inhibitor BMS inhibits the enzyme farnesyltransferase and the post-translational farnesylation of number of proteins involved in signal transduction, which may result in the inhibition of Ras function and apoptosis in susceptible tumor cells.

PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP―poly ADP ribose polymerase―in cancer therapy. The volume covers the history of the discovery of PARP and its role in DNA repair. Additionally, it describes the discovery of the PARP family, and includes a discussion of other DNA maintenance-associated : Nicola J.

Curtin. The farnesyltransferase inhibitors (FTIs) are a class of experimental cancer drugs that target protein farnesyltransferase with the downstream effect of preventing the proper functioning of the Ras (protein), which is commonly abnormally active in cancer.

Background. Studies have suggested that interference with certain post-translational modification processes seem to. The Role of Farnesyltransferase Inhibitors in Lung Cancer Therapy The Role of Farnesyltransferase Inhibitors in Lung Cancer Therapy Dy, Grace K.; Adjei, Alex A.

Protein farnesylation is required for the localization and function of several proteins pivotal to signal transduction pathways and cytoskeletal organization, including the Ras proteins.

Read "Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?, Biochimica et Biophysica Acta - Reviews on Cancer" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

Endocrine therapy combined with the farnesyltransferase inhibitor R produces enhanced tumour growth inhibition in hormone-sensitive MCF-7 human breast cancer xenografts in-vivo [abstract]. Breast Cancer Res Treat ().Cited by: Purpose This study explored the feasibility of treating patients with impaired hepatic function with tipifarnib.

The safety profile, pharmacokinetics, and relationship between the pharmacokinetics and toxicities were evaluated. Patients and Methods Patients with mildly or moderately impaired hepatic function (Child-Pugh classification) were treated with tipifarnib bid on days 1 to 5 of Cited by: 8.

Multiple farnesylated proteins are involved in signal transduction in cancer. Farnesyltransferase inhibitors (FTIs) have been developed as a strategy to inhibit the function of these proteins. As FTIs inhibit proliferation of melanoma cell lines, we undertook a study to assess the impact of a FTI in advanced melanoma.

As farnesylated proteins are also Cited by: Breast Cancer Research Vol 6 No 6 Head and Johnston Introduction Farnesyltransferase inhibitors (FTIs), initially developed to target cancers in which the ras proto-oncogene was mutated and overactive, represent a novel form of anticancer therapy.

However, in many tumours that lack ras mutations, activation of Ras protein may still occur. Introduction. Farnesyltransferase inhibitors (FTIs), initially developed to target cancers in which the ras proto-oncogene was mutated and overactive, represent a novel form of anticancer r, in many tumours that lack ras mutations, activation of Ras protein may still occur because of permanent upstream growth factor carcinomas are known to.

Aromatase inhibitors (AIs) are a class of drugs used in the treatment of breast cancer in postmenopausal women and gynecomastia in men. They may also be used off-label to reduce estrogen conversion when using external testosterone.

They may also be used for chemoprevention in high risk women. Aromatase is the enzyme that catalyzes a key ATC code: L02BG. pdf FTase inhibitors are currently in clinical trials for the treatment of cancer 2,3,4.

Here we present a complete series of structures representing the Cited by:   A phase I trial of the farnesyl transferase inhibitor SCH evidence for biological and clinical activity. Cancer Res. ; Kies MS, Clayman GI, El-Naggar AK, et al. Induction therapy with SCHa farnesyltransferase inhibitor, in squamous cell carcinoma (SCC) of the head and neck.

Purpose A dose-escalation phase I and pharmacokinetic study of the farnesyltransferase ebook lonafarnib (SCH) was conducted in children with recurrent or progressive CNS tumors. Primary objectives were to estimate the maximum-tolerated dose (MTD) and to describe the dose-limiting toxicities (DLTs) and pharmacokinetics of lonafarnib.

Cited by: